Title: Genotype, serum level of HCV-RNA and response to interferon-alpha treatment in patients with chronic hepatitis C
Authors: Clarysse, C ×
Van den Eynde, C
Nevens, Frederik
Portier, C
Aelbrecht, N
Fevery, Johan
Yap, Sing Hiem #
Issue Date: Mar-1996
Series Title: The Netherlands journal of medicine vol:47 issue:6 pages:265-71
Abstract: OBJECTIVE: Since only a small proportion of patients with chronic hepatitis C benefit from interferon therapy, we assessed the viral factors such as HCV genotype and the level of viraemia for prediction of interferon response. METHODS: HCV genotype and serum levels of HCV-RNA were determined in 24 patients before, during and after interferon treatment. RESULTS: Pre-treatment serum levels of HCV-RNA were significantly lower in patients with normalization of serum ALT and disappearance of serum HCV-RNA upon therapy than in patients with persistent abnormal ALT and/or serum HCV-RNA positivity. Sole infection with HCV genotype 1b was associated with a significantly higher pre-treatment serum HCV-RNA level than infection with genotype other than 1b or mixed types. CONCLUSIONS: HCV genotype and pre-treatment serum HCV-RNA levels are indeed important predictors for response to interferon treatment in patients with chronic hepatitis C.
ISSN: 0300-2977
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Hepatology
× corresponding author
# (joint) last author

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