Title: Starling resistor vs. distensible vessel models for embolic pulmonary hypertension
Authors: Mélot, C
Delcroix, Marion
Closset, J
Vanderhoeft, P
Lejeune, P
Leeman, M
Naeije, R #
Issue Date: Mar-1995
Series Title: The American journal of physiology vol:268 issue:2 Pt 2 pages:H817-27
Abstract: We investigated whether the Starling resistor model (Mitzner et al. J. Appl. Physiol. 51: 1065-1071, 1981) or a distensible vessel model (Haworth et al. J. Appl. Physiol. 70: 15-26, 1991) best describes pulmonary vascular pressure-flow (Q) relationships in embolic pulmonary hypertension. Mean pulmonary arterial pressure (Ppa)-Q plots at constant left atrial pressure (Pla) and Ppa-Pla plots at constant Q were investigated in seven dogs before and after 500-micron glass bead pulmonary embolism. Embolization to a mean angiographic obstruction of 78% increased the slope and extrapolated pressure intercept (P(i)) of Ppa-Q plots and increased the inflection point of Ppa-Pla plots, above which an increase in Pla is transmitted to Ppa in a ratio of approximately 1:1. The Starling resistor and the distensible vessel model provided a reasonably good fit to the Ppa-Q and Ppa-Pla coordinates before and after embolism. However, contrary to the prediction of the Starling resistor model, no correlation was found between the inflection point of Ppa-Pla plots and P(i). We therefore conclude that an increased closing pressure is unlikely to contribute to embolic pulmonary hypertension.
ISSN: 0002-9513
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Pneumology
# (joint) last author

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