Title: Synthesis and biophysical characterization of G-rich oligonucleotides conjugated with sugar-phosphate tails
Authors: D'Onofrio, J ×
Erra, E
Di Fabio, G
Iadonisi, A
Petraccone, L
De Napoli, L
Barone, G
Balzarini, Jan
Giancola, C
Montesarchio, D #
Issue Date: 2007
Publisher: Marcel Dekker
Series Title: Nucleosides, Nucleotides & Nucleic Acids vol:26 issue:10-12 pages:1225-1229
Conference: XVII International Round Table on Nucleosides, Nucleotides and Nucleic Acids location:Bern, Switzerland date:3-7 September 2006
Abstract: A number of 5'-and 3'-glycoconjugates of the oligonucleotide (5') d(TGGGAG)(3') have been synthesized, exploiting fully automated, online phosphoramidite-based solid phase strategy, as potential anti-HIV-1 agents. The thermodynamic stability of the resulting quadruplexes has been investigated by thermal denaturation studies, via a detailed CD analysis.
ISSN: 1525-7770
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Virology and Chemotherapy (Rega Institute)
× corresponding author
# (joint) last author

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