Title: Antiviral activity of 3-(3,5-dimethylbenzyl)uracil derivatives against HIV-1 and HCMV
Authors: Maruyama, Tokumi ×
Demizu, Yosuke
Kozai, Shigetada
Witvrouw, Myriam
Pannecouque, Christophe
Balzarini, Jan
Snoeck, Robert
Andrei, Graciela
De Clercq, Erik #
Issue Date: 2007
Publisher: Marcel Dekker
Series Title: Nucleosides, Nucleotides & Nucleic Acids vol:26 issue:10-12 pages:1553-1558
Conference: XVII International Round Table on Nucleosides, Nucleotides and Nucleic Acids location:Bern, Switzerland date:3-7 September 2006
Abstract: Antiviral activity of 1,3-disubstituted uracil derivatives was evaluated against HIV-1 and HCMV It appears that the nitrogen of the 1-cyanomethyl group is important for anti-HIV-1 activity, suggesting interaction with the amino acid residues of HIV-1 reverse transcriptase. 1-Arylmethyl derivatives also exhibited good anti-HIV-1 activity; and that of the 2- and 4-picolyl derivatives was particularly excellent.
ISSN: 1525-7770
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Virology and Chemotherapy (Rega Institute)
× corresponding author
# (joint) last author

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