Title: 5-Diacetoxymethyl-cycloSal-d4TMP - A prototype of enzymatically activated cycloSal-pronucleotides
Authors: Gisch, N ×
Balzarini, Jan
Meier, C #
Issue Date: 2007
Publisher: Marcel Dekker
Series Title: Nucleosides, Nucleotides & Nucleic Acids vol:26 issue:6-7 pages:861-864
Conference: XVII International Round Table on Nucleosides, Nucleotides and Nucleic Acids location:Bern, Switzerland date:3-7 September 2006
Abstract: A new class of "lock-in" modified cyclo Sal-pronucleotides has been synthesized. On the example of 5-diacetoxymethyl-cycloSal-d4T-monophosphate (5-di-AM-cycloSal-d4TMP), the concept of enzymatically activated cycloSal-pronucleotides is elucidated. Synthesis, hydrolysis studies, and antiviral activities against HIV are presented.
ISSN: 1525-7770
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Virology and Chemotherapy (Rega Institute)
× corresponding author
# (joint) last author

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