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Title: (R)-1-{(2-oxo-1,2-dihydroquinolin-6-yl)[3-(trifluoro-methyl)phenyl]methyl}-1H-1,2,4-triazol-4-ium bromide
Authors: Peeters, Oswald ×
Blaton, Norbert
De Ranter, Camiel #
Issue Date: Jul-2001
Publisher: Munksgaard int publ ltd
Series Title: Acta Crystallographica E, Structure Reports Online vol:57 pages:o655-o656
Abstract: The metabolism of all-trans-retinoic acid is mediated by a cytochrome dependent P-450 system. The title compound, C19H14F3N4O+. Br- (R111214), is an inhibitor of P-450. The three planar ring systems, viz. the triazolyl, phenyl and quinolinone groups, are arranged in a propeller-like fashion around the central CH group. The dihedral angles formed by the triazolyl/phenyl, triazolyl/quinolinone and phenyl/quinolinone planes are 55.8 (1), 79.85 (9) and 78.49 (9)degrees, respectively. The N-H . . .O hydrogen bonds, involving the triazolium N-H group and the quinolinone O atom, link the cations into infinite chains stretching along the c axis of the crystal.
ISSN: 1600-5368
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Biocrystallography
× corresponding author
# (joint) last author

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