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Title: Effect of staphylococcal enterotoxin B injection on the development of experimental autoimmune encephalomyelitis: influence of cytokine and inducible nitric oxide synthase production
Authors: Kuschnaroff, L M *
Overbergh, Lutgart *
Sefriouni, H
Sobis, H
Vandeputte, Michel
Waer, Mark # ×
Issue Date: 29-Oct-1999
Series Title: Journal of neuroimmunology vol:99 issue:2 pages:157-68
Abstract: Possible mechanisms involved in the protective effect of staphylococcal enterotoxin B (SEB) injection on the subsequent development of experimental autoimmune encephalomyelitis (EAE) were investigated. Only partial clonal deletion and anergy of Vbeta8 + T-lymphocytes were documented after myelin basic protein immunization in SEB injected mice. Brain permeability was not influenced. Within the brain or during in vitro rechallenge assays SEB protected mice produced significantly more IL-10, IL-4, TNF-alpha and iNOS. It is suggested that the immune deviating effect of SEB may be involved in its EAE protective effect.
ISSN: 0165-5728
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Nephrology
Clinical and Experimental Endocrinology
Laboratory of Experimental Transplantation
* (joint) first author
× corresponding author
# (joint) last author

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