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Title: Combined asthma and alveolitis induced by cobalt in a diamond polisher
Authors: Van Cutsem, E J ×
Ceuppens, Jan
Lacquet, L M
Demedts, Maurice #
Issue Date: Apr-1987
Series Title: European journal of respiratory diseases vol:70 issue:1 pages:54-61
Abstract: A diamond polisher presented with a history of dyspnea, chest tightness, chills and weight loss related to exposure to diamond cobalt disks at work. Pulmonary function showed slightly reduced lung volumes, low normal diffusing capacity and a moderate bronchial hyperresponsiveness to histamine. Chest X-ray and cell count in bronchoalveolar lavage fluid were normal. After 3 months of non-exposure, a bronchial cobalt challenge test caused an immediate decrease in specific airway conductance and in vital capacity (VC) but not in FEV1/VC. After 6 h, chills, fever, tachycardia and crackles appeared along with moderate reductions in lung volumes. After 24 h, the bronchoalveolar lavage fluid showed 43% granulocytes, and there was a marked increase in bronchial hyperresponsiveness to histamine. These changes are interpreted as combined asthma and alveolitis induced by cobalt.
ISSN: 0106-4339
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Pneumology
Laboratory of Clinical Immunology
× corresponding author
# (joint) last author

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