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Title: Dynamic contrast-enhanced MRI of the pancreas: initial results in healthy volunteers and patients with chronic pancreatitis
Authors: Coenegrachts, Kenneth ×
Van Steenbergen, Werner
De Keyzer, Frederik
Vanbeckevoort, Dirk
Bielen, Didier
Chen, Feng
Dockx, Steven
Maes, Frederik
Bosmans, Hilde #
Issue Date: Dec-2004
Publisher: Society for Magnetic Resonance Imaging
Series Title: Journal of magnetic resonance imaging vol:20 issue:6 pages:990-997
Abstract: PURPOSE: To characterize pancreatic perfusion in volunteers and patients with chronic pancreatitis (CP) by dynamic contrast-enhanced (DCE) MRI. MATERIALS AND METHODS: Pancreatic enhancement after bolus injection of Gd-DTPA with a three-dimensional ultrafast partial-Fourier radiofrequency (RF) spoiled gradient-echo (GE) acquisition was examined prospectively. An acquisition volume of the pancreatic parenchyma was obtained every 4.2 seconds during a single breath-hold in 31 volunteers and 19 patients with CP. We calculated the wash-in rate and a newly defined parameter, the "time-to-inflow deceleration" (TID). A statistical analysis of the differences between both groups was performed with the use of Student's t-test. RESULTS: Significant differences in the TID and wash-in rate were found for the head and body of the pancreas: the TID was 22.4 sec +/- 4.4 sec and 23.5 sec +/- 6.1 sec in the pancreatic head and body of the healthy volunteers, and 29.8 sec +/- 8.6 sec and 29.4 sec +/- 3.8 sec in patients with CP. The wash-in rate was 96 +/- 37 sec(-1) and 101 +/- 27 sec(-1) in controls, and 62 +/- 17 sec(-1) and 75 +/- 27 sec(-1) in CP. CONCLUSION: CP can be identified by semiquantitative changes on DCE-MRI. Whether DCE-MRI of the pancreas can be used to detect early CP remains to be validated.
ISSN: 1053-1807
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Radiology
ESAT - PSI, Processing Speech and Images
Theragnostic Laboratory (+)
× corresponding author
# (joint) last author

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