Title: Effect of rioprostil, 600 micrograms, on the interdigestive myoelectrical activity of the humans small intestine
Authors: Vantrappen, Gaston ×
Janssens, Jozef #
Issue Date: Dec-1989
Series Title: Scandinavian journal of gastroenterology. Supplement vol:164 pages:133-8; discussion 138-9
Abstract: The effect of rioprostil, a PGE1 analogue, on the interdigestive motility of the upper human small intestine was investigated in 8 normal volunteers in a double-blind, placebo-controlled study. Rioprostil was administered intraduodenally in a dose of 600 micrograms. The myoelectrical activity was recorded simultaneously at 8 different levels of the jejunum, at 10 cm intervals. Rioprostil, 600 micrograms, does not disrupt the migrating motor complex (MMC) and does not change the characteristics of phase 3 of the MMC, except for an increased propagation velocity. The main effect of rioprostil, 600 micrograms, is a marked inhibition of phase 2 contractions without induction of propulsive motility patterns during phase 2. This may explain why rioprostil in a dose of 600 micrograms is not markedly diarrheogenic in man.
ISSN: 0085-5928
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Translational Research in GastroIntestinal Disorders
× corresponding author
# (joint) last author

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