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Title: Tenascin and strictures in inflammatory bowel disease: an immunohistochemical study
Authors: Geboes, Karel ×
El-Zine, M Y
Dalle, Ignace
El-Haddad, S
Rutgeerts, Paul
Van Eyken, P #
Issue Date: Oct-2001
Series Title: International journal of surgical pathology vol:9 issue:4 pages:281-6
Abstract: Tenascin is an extracellular matrix protein involved in morphogenesis of muscle tissue and in wound healing. In the present study we examined its distribution in tissue from patients with inflammatory bowel disease. Intestinal biopsies from 10 normal controls, 15 patients with Crohn's disease, and 6 with ulcerative colitis were studied. Samples were obtained both from uninvolved and involved areas. Mucosal tenascin is increased in ulcerative colitis and Crohn's disease, especially in areas of ulceration. In Crohn's disease, tenascin is also strongly expressed in the submucosa and in smooth muscle cells of the muscularis mucosae and propria, especially in areas of stricture. We conclude that tenascin is involved in stricture formation in Crohn's disease and that it is a marker of phenotypic change in smooth muscle cells.
ISSN: 1066-8969
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Translational Research in GastroIntestinal Disorders
Translational Cell & Tissue Research
× corresponding author
# (joint) last author

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