Title: APP23 mice display working memory impairment in the plus-shaped water maze
Authors: Vloeberghs, E ×
Van Dam, D
D'Hooge, Rudi
Staufenbiel, M
De Deyn, P.P #
Issue Date: 2006
Publisher: Elsevier/North-Holland
Series Title: Neuroscience Letters vol:407 issue:1 pages:6-10
Abstract: Alzheimer's disease (AD) patients typically present short-term memory deficits, before long-term memory capacity declines with disease progression. Several studies have described learning and memory deficits in the APP23 mouse model. Our group reported a decline of learning and memory capacities from the age of 3 months onwards using a hidden-platform Morris water maze (MWM). The aim of the present study was to evaluate working and reference memory in APP23 mice in the same plus-shaped water maze. The transgenic mice had slower learning curves; however, consolidation of the learned information appeared intact in this learning paradigm. This report demonstrates impairment of working memory in this transgenic Alzheimer model
Description: 01
ISSN: 0304-3940
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory for Biological Psychology
Faculty of Psychology and Educational Sciences - miscellaneous
× corresponding author
# (joint) last author

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