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Title: Renal cadaveric transplantation in diabetics using total lymphoid irradiation or cyclosporin A. A controlled randomized study. Leuven Collaborative Transplantation Group
Authors: Waer, Mark ×
Vanrenterghem, Yves
Roels, L
Verberckmoes, René
Hauglustaine, D
van der Schueren, E
Lerut, Antoon
Gruwez, Jacques
Bouillon, Roger
Vandeputte, Michel
Michielsen, Paul #
Issue Date: Jul-1988
Series Title: Transplant International vol:1 issue:2 pages:64-8
Abstract: A total of 20 renal transplant patients with end-stage diabetic nephropathy entered a randomized controlled trial comparing preoperative, fractionated total lymphoid irradiation (TLI) (radiation dose, 20-30 Gy) with postoperative cyclosporin A (CsA). Both groups received postoperative low-dose methylprednisolone maintenance therapy. The 3-year patient and graft survival was similar for both groups (100% and 71% in the TLI and 75% and 75% in the CsA group, respectively). Rejection crises occurred significantly more frequently (P less than 0.01) in the TLI-treated recipients. The incidence of infectious or diabetic complications was not significantly different in both groups. It is concluded that TLI and CsA are both effective treatment modalities for cadaveric renal transplantation in diabetics; CsA, however, is superior in preventing rejection crises.
ISSN: 0934-0874
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Nephrology
Clinical and Experimental Endocrinology
Thoracic Surgery
Laboratory of Experimental Transplantation
× corresponding author
# (joint) last author

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