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Title: Cimetidine-induced liver injury. Report of three cases
Authors: Van Steenbergen, Werner ×
Vanstapel, M J
Desmet, Valeer
Van Kerckvoorde, L
De Keyzer, R
Brijs, R
Fevery, Johan
De Groote, Jan #
Issue Date: Dec-1985
Series Title: Journal of hepatology vol:1 issue:4 pages:359-68
Abstract: Cimetidine-induced liver injury has only very rarely been reported. Three patients are described who developed signs of hepatic damage after the institution of cimetidine therapy. Transient signs of acute liver failure were noticed in one patient. Histologically, a cytotoxic type of injury with centrilobular confluent and bridging portal-central necrosis, accompanied by a mixed mono- and polymorphonuclear infiltrate with signs of cholangiolitis in the portal tracts was observed in two patients, whereas a hepatocanalicular type of cholestatic hepatitis was noticed in another patient. It is proposed that the mechanism of cimetidine-induced liver injury may vary in different patients: it may be due either to a 'metabolic idiosyncrasy' because of the production of hitherto unknown toxic metabolites or to a hypersensitivity reaction.
ISSN: 0168-8278
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Hepatology
Translational Cell & Tissue Research
× corresponding author
# (joint) last author

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