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Title: Effects of unilateral hypoxia on neuroepithelial bodies in rabbit lungs
Authors: Lauweryns, J M ×
De Bock, Vera
Guelinckx, Julien
Decramer, Marc #
Issue Date: Feb-1984
Series Title: Journal of applied physiology: respiratory, environmental and exercise physiology vol:55 issue:6 pages:1665-8
Abstract: The present study was undertaken to investigate the influence of regional (unilateral) alveolar hypoxia on the intrapulmonary neuroepithelial bodies (NEB), which contain bioactive substances and are distinctly innervated. Eight (4-wk-old) rabbits were subjected to unilateral hypoxia. The animals were anesthetized by an intramuscular injection of Hypnorm and breathed spontaneously during the experiment. The right lung received a hypoxic gas mixture (10% O2-90% N2) and the left lung a hyperoxic mixture. Blood gas measurements indicated that no systemic hypoxemia or acidosis occurred under these conditions. Lung samples were examined by electron microscopy to determine morphometrically the extent of a secretory exocytosis at the basal cell pole of the NEB and by a microspectrographical analysis of the formaldehyde-induced fluorescence to quantify the NEB serotonin content. After 20 min of unilateral hypoxia the NEB in the right hypoxic lung exhibited an increased exocytosis and a lower serotonin content in comparison with the left hyperoxic lung NEB. These results indicate that NEB react to regional alveolar hypoxia by secreting serotonin and/or peptides to the surrounding lung tissue (blood vessels, smooth muscle, nerve endings, etc.).
URI: 
ISSN: 0161-7567
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Faculty of Medicine - miscellaneous
Pneumology
× corresponding author
# (joint) last author

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