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Title: Primary human hepatocytes are protected against prolonged and repeated exposure to ethanol by silibinin-dihemisuccinate
Authors: van Pelt, Jos ×
Verslype, Chris
Crabbé, Martine
Zaman, Zahur
Fevery, Johan #
Issue Date: Aug-2003
Series Title: Alcohol and Alcoholism vol:38 issue:5 pages:411-4
Abstract: AIMS AND METHODS: We investigated the effect of silibinin-C-2',3'-dihydrogensuccinate (SDH) on primary human hepatocytes when exposed to ethanol for 14 days. At regular intervals, the medium was refreshed and liver enzymes and secreted protein in the medium were determined. RESULTS: The ethanol-induced release of lactate dehydrogenase (at 34 mM ethanol) was completely blocked by 20 microM SDH. SDH itself stimulated fibrinogen release and had no toxic effect. CONCLUSIONS: We can conclude that SDH has a beneficial effect on human hepatocytes when exposed to ethanol in vitro.
ISSN: 0735-0414
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Hepatology
Laboratory of Clinical Bacteriology and Mycology
× corresponding author
# (joint) last author

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