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Title: Duplex Doppler evaluation of renal allograft dysfunction: Doppler signal quantitation and pathologic correlation
Authors: Rigauts, Hans ×
Marchal, Guy
Grieten, M
Van Damme, Boudewijn
Vanrenterghem, Yves
Waer, Mark
Verbrugge, H #
Issue Date: Nov-1990
Series Title: Journal Belge de Radiologie vol:73 issue:6 pages:475-83
Abstract: The value of quantitative duplex Doppler sonography in discriminating the different possible causes of renal transplant dysfunction was prospectively studied in 60 patients during 65 episodes of renal function impairment. Final diagnosis at histology was acute rejection (n: 30), acute tubular necrosis (n: 4), cyclosporin nephrotoxicity (n: 16) and chronic rejection (n: 15). Duplex sonography was done the day a percutaneous biopsy was taken and before any therapy was started. Arterial Doppler signals obtained from the segmental, interlobar and arcuate arteries were both morphologically and quantitatively analysed. For quantitative analysis we used the resistive index as proposed by Pourcelot on the one hand, and introduced a variant resistive index on the other hand. Morphological analysis yielded no discriminative value. Comparing both quantitative methods--the resistive index of Pourcelot and the variant resistive index--clearly higher specificities--71% using the variant resistive index, 28% using the resistive index of Pourcelot--for excluding acute rejection from the other possible causes of renal function impairment could be achieved. A nephrectomy was done on 7 patients with severe transplant dysfunction. Microangiographies performed on these nephrectomy specimens were correlated with previous Doppler studies and with histology.
ISSN: 0021-7646
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Nephrology
Translational Cell & Tissue Research
Laboratory of Experimental Transplantation
× corresponding author
# (joint) last author

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