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Title: Overexpression of indoleamine 2,3-dioxygenase in human inflammatory bowel disease
Authors: Wolf, Anna Maria ×
Wolf, Dominik
Rumpold, Holger
Moschen, Alexander R
Kaser, Arthur
Obrist, Peter
Fuchs, Dietmar
Brandacher, Gerald
Winkler, Christiane
Geboes, Karel
Rutgeerts, Paul
Tilg, Herbert #
Issue Date: Sep-2004
Publisher: Academic Press
Series Title: Clinical Immunology vol:113 issue:1 pages:47-55
Abstract: T-cells are causally involved in the pathogenesis of inflammatory bowel disease (IBD). The tryptophan-metabolizing enzyme indoleamine 2,3-dioxygenase (IDO) regulates T-cell proliferation and survival. We show in this report that IDO mRNA is markedly induced in lesional colonic biopsies of IBD patients. IDO is primarily expressed in CD123(+) mononuclear cells infiltrating the submucosal areas of the inflamed lesions. In Crohn's disease (CD), IDO is also strongly expressed in perifollicular regions of lymphoid follicles. Upregulation of IDO is of functional significance, as we detected an increase of kynurenine and of the kynurenine/tryptophan ratio in supernatants from colonic explant cultures (CECs) of CD patients. Immunohistochemistry of colonic biopsies taken from CD patients prior and after treatment with the TNF-blocking antibody Infliximab revealed reduced IDO expression in patients with good clinical response to Infliximab. In summary, high local expression of IDO may represent an anti-inflammatory mechanism tempting to counterbalance the tissue-damaging effects of activated T-cells infiltrating the colonic mucosa in IBD.
URI: 
ISSN: 1521-6616
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Translational Cell & Tissue Research
Translational Research in GastroIntestinal Disorders
× corresponding author
# (joint) last author

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