This item still needs to be validated !
Title: Heparan sulfate proteoglycans. Essential co-factors in receptor-mediated processes with relevance to the biology of the vascular wall
Authors: David, Guido ×
Danneels, Anne
Duerr, Joachim
Grootjans, Johan
Mertens, Griet
Nackaerts, Kristiaan
Romaris, Manuel
Schrurs, Brigitte
Steinfeld, Robert
Vekemans, Sylvie #
Issue Date: Dec-1995
Publisher: Elsevier sci ireland ltd
Series Title: Atherosclerosis vol:118 Suppl pages:S57-67
Abstract: Heparan sulfate (HS), a mixed bag of complex, heterogeneous and highly charged polysaccharides, is an essential co-factor in a large number of receptor-ligand interactions and cellular pathways. These co-factor functions depend on the binding-interactions of the HS chains with the ligand or receptor, or both. These binding interactions and the ensuing functional effects often depend on defined carbohydrate sequences within the HS chains, whereby the required sequences are not always represented within all natural forms of the polysaccharide. The proteins that are substituted with HS resort from a limited number of protein families, with different cellular, subcellular and supramolecular associations, and show differential activities in functional assays. It is likely that the natural co-factor functions of the HS proteoglycans depend on glycan-protein and protein-protein interactions that are subject to modulation, both at the glycan and protein levels.
ISSN: 0021-9150
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Molecular Genetics Section (-)
Division Forest, Nature and Landscape Research
Leuven Language Institute (ILT)
Department of Human Genetics - miscellaneous
× corresponding author
# (joint) last author

Files in This Item:

There are no files associated with this item.

Request a copy


All items in Lirias are protected by copyright, with all rights reserved.

© Web of science