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Title: Histology may depend on the presence of partial monosomy or partial trisomy 3 in renal cell carcinoma
Authors: Balzarini, Piera ×
Dal Cin, Paola
Roskams, Tania
Polito, Pietro
Van Poppel, Hendrik
Van Damme, Boudewijn
Baert, Luc
Van den Berghe, Herman #
Issue Date: Aug-1998
Series Title: Cancer genetics and cytogenetics vol:105 issue:1 pages:6-10
Abstract: Rearrangements of 3q were found in 10% of a series of 230 cases of renal cell carcinoma (RCC). Together with observations from the literature, these structural changes can be concluded to involve two different regions, 3q21 and 3q11-12, and are usually present as unbalanced translocations. In some of these cases of RCC with the translocation, the normal chromosome 3 may reduplicate, giving rise to a partial trisomy 3q instead of a partial monosomy 3. In those cases, however, histology shows chromophilic-papillary RCC instead of clear cell-nonpapillary. Hence, besides the still unresolved underlying molecular changes causing RCC, histology may in part depend on the presence of partial monosomy or partial trisomy 3.
ISSN: 0165-4608
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Translational Cell & Tissue Research
Urology Section (-)
Clinical Genetics Section (-)
Department of Human Genetics - miscellaneous
× corresponding author
# (joint) last author

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