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Title: Regulation of maltose utilization in Saccharomyces cerevisiae by genes of the RAS protein kinase A pathway
Authors: Wanke, V ×
Vavassori, M
Thevelein, Johan
Tortora, P
Vanoni, M #
Issue Date: 1997
Publisher: ELSEVIER SCIENCE BV
Series Title: FEBS Letters vol:402 issue:2-3 pages:251-255
Conference: date:UNIV MILAN,DIPARTIMENTO FISIOL & BIOCHIM GEN,SEZ BIOCHIM COMPARATA,I-20133 MILAN,ITALY; KATHOLIEKE UNIV LEUVEN,LAB MOL CELBIOL,B-3001 LOUVAIN,BELGIUM; UNIV MILAN,DIPARTIMENTO FISIOL & BIOCHIM GEN,SEZ CHIM BIOL,I-20133 MILAN,ITALY
Abstract: In Saccharomyces cerevisiae maltose utilization requires a functional MAL locus, each composed of three genes: MALR (gene 3) encoding a regulatory protein, MALT (gene 1) encoding maltose permease and MALS (gene 2) encoding maltase, We show that constitutive activation of the RAS/ protein kinase A pathway severely reduces growth of MAL1 strains on maltose, This may be a consequence of reduction in MALT mRNA, reduced V-max and increased catabolite inactivation of the MALT-encoded maltose transporter in the MAL1 strain, Mutations in the GGS1/TPS1 gene, which restricts glucose influx and possibly affects signalling, relieve carbon catabolite repression on both maltase and maltose permease and reduce maltose permease inactivation.
ISSN: 0014-5793
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Molecular Microbiology and Biotechnology Section - miscellaneous
× corresponding author
# (joint) last author

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