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Title: An experimental evaluation of three preoperative radiation regimens for resectable rectal cancer
Authors: Basha, Genc ×
Landuyt, Willy
Fowler, Jack
Vordermark, Dirk
Haustermans, Karin
Geboes, Karel
Van den Bogaert, Walter
Yap, Sing Hiem
Lambin, Philippe
Penninckx, Freddy #
Issue Date: Apr-2002
Publisher: Raven Press
Series Title: Annals of surgical oncology vol:9 issue:3 pages:292-297
Abstract: BACKGROUND: We investigated the degree of tumor cell killing after radiotherapy regimens commonly used in clinical practice in comparison with an accelerated schedule. METHODS: Mtln3 mammary adenocarcinoma tumor cells were inoculated subcutaneously in the hind leg of syngeneic Fischer 344 rats. Tumors were irradiated with 5 x 5 Gy in 5 days, 10 x 3 Gy over 10 days, or 5 x (2 x 3) Gy in 5 days. After excision of the irradiated tumors, the dye exclusion, a tetrazolium-based colorimetric and the clonogenic assays were used to determine tumor cell viability and surviving fractions. RESULTS: Estimated potential doubling time values indicate a rapid proliferation capacity, comparable with potential doubling time values in human rectal cancer. The dye exclusion and clonogenic assays revealed a significantly higher degree of cell killing after the hypofractionated and the accelerated regimens of, respectively, 5 x 5 Gy and 5 x (2 x 3) Gy over 5 days compared with 10 x 3 Gy over 10 days. CONCLUSIONS: A shorter treatment time offered the best therapeutic efficacy. The schedule involving two daily fractions of 3 Gy over 5 days should be less toxic than 5 x 5 Gy and may therefore provide a therapeutic advantage.
ISSN: 1068-9265
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Translational Cell & Tissue Research
Abdominal Surgical Oncology
Laboratory of Experimental Radiotherapy
× corresponding author
# (joint) last author

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