Title: Optimal experimental design for practical identification of unstructured growth models
Authors: Versyck, KJ ×
Claes, Johan
Van Impe, Jan #
Issue Date: 1998
Series Title: Mathematics and computers in simulation vol:46 issue:5-6 pages:621-629
Conference: date:Katholieke Univ Leuven, Dept Food & Microbial Technol, B-3001 Heverlee, Belgium
Abstract: In this paper, optimal experimental design for parameter estimation of unstructured microbial growth models during growth of biomass on a single limiting substrate in a fed-batch bioreactor is considered. The ratio of the largest to the smallest eigenvalue of the Fisher information matrix (i.e,, the modified E-criterion for optimal experimental design) is used to evaluate the information content of several simulation fed-batch experiments, each with a different volumetric feed rate profile. The construction of optimal feed rate profiles is based on the following Conjecture: A feed rate strategy which is optimal in the sense of process performance, is an excellent starting point for feed rate optimization with respect to estimation of those parameters with a large influence upon process performance. The optimal value of 1 for the modified E-criterion is obtained for several feed rate profiles with different structures, after optimization of their corresponding degrees of freedom with respect to the information content of the experiment. For each profile a criterion evaluating the violation of model validity is calculated. (C) 1998 IMACS/Elsevier Science B.V.
ISSN: 0378-4754
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Bio- & Chemical Systems Technology, Reactor Engineering and Safety Section
Bioengineering Technology TC, Technology Campus Geel
Technologiecluster Bioengineering Technologie
× corresponding author
# (joint) last author

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