Title: Feed rate optimization for fed-batch bioreactors: From optimal process performance to optimal parameter estimation
Authors: Versyck, KJ ×
Van Impe, Jan #
Issue Date: 1999
Publisher: Gordon and Breach
Series Title: Chemical Engineering Communications vol:172 pages:107-124
Conference: date:Katholieke Univ Leuven, Dept Food & Microbial TEchnol, BioTec Bioproc Technol & Control, B-3001 Louvain, Belgium
Abstract: In this paper the optimization of a cost criterion combining both a performance cost and a parameter identification cost is discussed for the growth of biomass on one limiting substrate in a fed-batch bioreactor. Both monotonic and non-monotonic unstructured kinetic models in which the specific growth rate is a function of the substrate concentration only are considered. The parametric optimization of the feed rate profile in the fed-batch bioreactor with respect to a novel combined cost function yields a continuous transformation of the optimal performance feed rate profile towards the optimal identification profile as more weight is assigned to the identification purpose. As such we provide support for the conjecture that a feed rate strategy which is optimal in the sense of process performance, is an excellent starting point for feed rate optimization with respect to estimation of those parameters with large influence upon process performance.
ISSN: 0098-6445
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Bio- & Chemical Systems Technology, Reactor Engineering and Safety Section
× corresponding author
# (joint) last author

Files in This Item:

There are no files associated with this item.

Request a copy


All items in Lirias are protected by copyright, with all rights reserved.

© Web of science