Title: Optimal design of a closed loop controller for estimation of parameter couples of microbial growth kinetics
Authors: Versyck, KJ ×
Van Impe, Jan #
Issue Date: 2000
Publisher: Gordon and Breach
Series Title: Chemical Engineering Communications vol:180 pages:39-59
Conference: date:Katholieke Univ Leuven, Dept Food & Microbial Technol, B-3001 Louvain, Belgium
Abstract: This paper deals with the design of a feedback controller for the decorrelated estimation of a parameter couple appearing in an unstructured model for growth of one biomass on one limiting substrate in a fed-batch bioreactor. By optimal experimental design, feed rate strategies for decorrelated parameter estimation have been constructed las reported elsewhere). These profiles have in common a feeding phase in which the substrate concentration is kept constant at a setpoint value by a feedforward controller. On simulation level this controller can be applied as an open loop controller. However, in practice these feed rate strategies are to be implemented in closed loop. Since during experimental design on simulation level a nominal parameter set is required, an iterative approach is needed to end up with a truly optimal experiment for estimation of the unknown parameters. Such an iterative scheme is proposed and its convergence properties are discussed.
ISSN: 0098-6445
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Bio- & Chemical Systems Technology, Reactor Engineering and Safety Section
× corresponding author
# (joint) last author

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