Title: Feedback stabilization of fed-batch bioreactors: Non-monotonic growth kinetics
Authors: Smets, Ilse ×
Bastin, GP
Van Impe, Jan #
Issue Date: 2002
Series Title: Biotechnology Progress vol:18 issue:5 pages:1116-1125
Conference: date:Katholieke Univ Leuven, Dept Chem Engn, B-3001 Louvain, Belgium; Univ Catholique Louvain, CESAME, B-1348 Louvain, Belgium
Abstract: This paper deals with the design of a feedback controller for fed-batch microbial conversion processes that forces the substrate concentration C-S to a desired setpoint C-S*, starting from an arbitrary (initial) substrate concentration when non-monotonic growth kinetics apply. This problem is representative for a lot of industrial fermentation processes, with the baker's yeast fermentation as a well-known example. It is assumed that the specific growth rate mu is function of the substrate concentration only. A first approach exploits the availability of on-line measurements of both the substrate and biomass concentration. A second approach is merely based on on-line measurements of the biomass concentration, which provide an estimate for the specific growth rate. After a reformulation of the substrate concentration setpoint into a specific growth rate setpoint, it is demonstrated that the fed-batch process can still be stabilized around any desired operating point along the non-monotonic kinetics.
ISSN: 8756-7938
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Bio- & Chemical Systems Technology, Reactor Engineering and Safety Section
× corresponding author
# (joint) last author

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