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Title: The influence of occupational exposure to pesticides, polyclyclic aromatic hydrocarbons, diesel exhaust, metal dust, metal fumes, and mineral oil on prostate cancer: a prospective cohort study
Authors: Boers, D ×
Zeegers, Maurice
Swaen, GM
Kant, IJ
Van den Brandt, PA #
Issue Date: 2005
Series Title: BMJ (International Edition) vol:62 pages:531-537
Abstract: Aims: To investigate the relation between exposure to pesticides, polycylic aromatic hydrocarbons, diesel exhaust, metal dust, metal fumes, and mineral oil in relation to prostate cancer incidence in a large prospective study. Methods: This cohort study was conducted among 58279 men in the Netherlands. In September 1986, cohort members (55-69 year) completed a self-administered questionnaire on potential cancer risk factors, including job history. Follow up for prostate cancer incidence was established by linkage to cancer and 2335 subcohort members. A blinded case-by-case expert exposure for each potential carcinogenic exposure. Results: In multivariate analyses there was a significant negative association for pesticides (RR 0.60; 95% CI 0.37 to 0.95) when comparing the highest tertile of exposure to pesticides with no exposure. No association was found for occupational exposure to PAHs (RR 0.75; 95% CI 0.42 tot 1.31), diesel exhaust (RR 0.81; 95% CI0.62 to 1.06), metal dust (RR 1.01; 95% CI 0.72 tot 1.40), metal fumes (RR 1.11; 95% CI 0.80 to 1.54), or mineral oil (RR 0.99, 95% CI 0.66 to 1.48) when comparing the highest tertile of exposure with no exposure. In subgroups ananlysis, with respect to tumour invasiveness and morphology, null results were found for occupational exposure to pesticides, PAH, diesel exhaust, metal dust, metal fumes, and mineral oil. Conclusions: These results suggest a negative association between occupational exposure to pesticides and prostate cancer. For other carcinogenic exposures results suggest no association between occupational exposure to PAHsn diesel exhaust, metal dust, metal fumes, or mineral oil and prostate cancer.
ISSN: 1756-1833
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Academic Center for General Practice
× corresponding author
# (joint) last author

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