Association of vitiligo with HLA-A2: a meta-analysis
Liu, JB LM × Chen, H Zhong, SQ Yang, S Du, WD Hao, JH Zhang, TS Zhang, XJ Zeegers, Maurice #
Elsevier Science Publishers
Journal of the European Academy of Dermatology and Venereology vol:21 issue:2 pages:205-213
Background: Linkage and association studies suggest that the human leucocyte antigen (HLA° region may be involved in the genetic susceptiblity of vitiligo. HLA-A2 has been reported to be associated with vitiligo in some, but not allz, stuies. Objective: To identify sources of the heterogeneity among studies and to quantity effect estimates, we examined the association of HLA-A2 with vitigligo in a meta-analysis of all observational studies comparing the frequencies of HLA-A2 between vitiligo individuals and controls during 1966-2005. Methods: The summary odds ratio (OR) was calculated by using a fixed-or a random-effects model. Meta-regression analysis was undertaken to investigate the effects of study characteristics on the pooled OR. Results: Eleven case-controlled studies fulfilled our inclusion criteria. The studies identified a total of 777 patients and 4820 controls. Meta-analysis showed a significantly increased frequency of HLA-A2 in vitiligo among cases (OR= 2.07, 95%CI 1.67-2.58). Heteerogeneity was explained by the quality of the study and the ethnic background of the participants. Meta-regression analysis further showed that th percentage of familial vitiligo among the subjects had a significant effect on the pooled OR (P= 0.007). No study had a significant effect on the pooled OR and no publication bias presented in the studies analysed (P=0.688). Conclusion: These findings strongly suggest an association between HLA-A2 and vitiligo.