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Title: Combined liver and (heart-)lung transplantation in liver transplant candidates with refractory portopulmonary hypertension
Authors: Pirenne, Jacques ×
Verleden, Geert
Nevens, Frederik
Delcroix, Marion
Van Raemdonck, Dirk
Meyns, Bart
Herijgers, Paul
Daenen, Willem
De Leyn, Paul
Aerts, Raymond
Coosemans, Willy
Decaluwé, Herbert
Koek, Gerrit
Vanhaecke, Johan
Schetz, Miet
Verhaegen, Marleen
Cicalese, Luca
Benedetti, Enrico #
Issue Date: Jan-2002
Publisher: Lippincott Williams & Wilkins
Series Title: Transplantation vol:73 issue:1 pages:140-142
Abstract: BACKGROUND: Portopulmonary hypertension (PPHT) has a prevalence of 5-10% in liver transplantation (LiTx) candidates. Mild PPHT is reversible with LiTx, but more severe PPHT is a contraindication to LiTx given the high intraoperative mortality due to heart failure. Prostacyclin can reduce PPHT to a level at which LiTx can be performed. In patients refractory to that treatment, combined (heart-)lung-LiTx is the only life-saving option. METHODS: We report two cases of (heart-)lung-LiTx in patients with refractory severe PPHT. RESULTS: Patient 1, a 52-year-old female with viral cirrhosis and severe refractory PPHT, received a double-lung Tx followed by LiTx. After liver reperfusion, fatal heart failure occurred. Patient 2, a 42-year-old male with viral hepatitis and congenital liver fibrosis, also suffered from severe refractory PPHT. He successfully received an en bloc heart-lung Tx followed by LiTx. The rationale to replace the heart was an anticipated risk of intraoperative right heart failure after liver reperfusion and the technical ease of heart-lung versus double-lung Tx. CONCLUSION: Severe refractory PPHT is a fatal condition seen as a contraindication to LiTx. This condition can be treated by replacing thoracal organs in addition to the liver. Additional evidence via development of a registry is required to further support application of liver-(heart-)lung Tx in patients with severe refractory PPHT.
ISSN: 0041-1337
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Abdominal Transplantation
Thoracic Surgery
Experimental Cardiac Surgery
Clinical Cardiac Surgery
Laboratory of Intensive Care Medicine
Anesthesiology and Algology
Laboratory of Nephrology
× corresponding author
# (joint) last author

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