Pooled analysis and meta-analysis of the Gluthatione S-transferase P1 lle 105Val Polymorphism and bladder cancer: A HuGE-GSEC Review
Kellen, Eliane × Hemelt, M Broberg, K Golka, K Kristensen, VN Hung, RJ Matullo, G Mittal, RD Porru, S Povey, A Schulz, WA Shen, J Buntinx, Frank Zeegers, MPA Taloli, E #
School of Hygiene and Public Health of the Johns Hopkins University
American Journal of Epidemiology vol:165 issue:11 pages:1221-30
The glutathione S-tranferase P1 genotype (GSTP1) is involved in the inactivation of cigarette smoke carcinogens, and sequence variation in the gene may alter bladder cancer susceptibility. To examine the association between GSTP1lle 105Val and bladder cancer, the authors undertook a meta-and pooled analysis. Summary crude and adjusted odds ratios and corresponding 95% confidence intervals were pooled by using a random-effects model. In the meta-analysis (16 studies, 4,273 cases and 5,081 controls), the unadjusted summary odds ratios for GSTP1 lle/Val and Val/Val compared with GSTP1 lle/lle were 1.54 (95% CI: 1.21,1.99; p<0.001) and 2.17 (95% CI: 1.27, 3.71; p=0.005). The associationappeared to be the strongest in Asian countries. When the analysis was limited to European descendents (nine studies), the summary odds ratiodecreased (odds ratios= 1.24, 95% CI: 1.00, 1.52) (Q=17.50; p= 0.02). All relevant data previously contributed to the international study on genetic susceptibility to environmental carcinogens were pooled (eight studies, 1.305 cases and 1.588 controls). The summary odds ratios were similar to the ones from the meta-analysis. Case-only analyses did not detect an interaction between the GSTP1 genotype and smoking status (never/ever). GSTP1 lle 105Val appears to be associated with a modest increase in the risk of bladder cancer.