Title: Corticotropin-releasing hormone: A potent androgen secretagogue in girls with hyperandrogenism after precocious pubarche
Authors: Ibanez, L ×
Potau, N
Marcos, MV
de Zegher, Francis #
Issue Date: 1999
Series Title: Journal of Clinical Endocrinology and Metabolism vol:84 issue:12 pages:4602-4606
Conference: date:Univ Barcelona, Hosp St Joan de Deu, Endocrinol Unit, Barcelona 08950, Spain; Autonomous Univ Barcelona, Hosp Maternoinfantil Vall Hebron, Hormonal Lab, Barcelona, Spain; Consorsci Hosp Terrassa, Barcelona, Spain; Katholieke Univ Leuven, Dept Pediat, Louvain, Belgium
Abstract: CRH is an adrenal androgen secretagogue in men and has been proposed as a candidate regulator of adrenarche. CRH also affects androgen production by theca cells and may be involved in the pathogenesis of ovarian hyperandrogenism (OH). Precocious pubarche (PP) in girls can precede adolescent OH, a condition characterized by a high ovarian 17-hydroxyprogesterone (17-OHP) response 24 h after GnRH agonist challenge. In adolescent girls with a history of PP, we assessed the early androgen response to CRH, as well as the CRH effect on the late ovarian response to GnRH agonist. Within a randomized cross-over design, saline or CRH (human CRH 1 mu g/kg.h in saline) was infused over 3-h (1100-1400 h) into 12 adolescent girls (age 17 +/- 2 yr; body mass index 21.4 +/- 0.9 Kg/m(2)) who had been pretreated with dexamethasone (1 mg at 0 h) and GnRH agonist (leuprolide acetate 500 mu g sc at 0800 h = time 0). All adolescents had hirsutism, irregular menses, hyperandrogenemia, and hyperinsulinemia after PP. Serum LH, FSH, androstenedione, dehydroepiandrosterone (DHEA), and DHEA-sulfate (DHEAS) were measured at time 0, 3, 6, and 24 h, and ACTH and 17-OHP were measured at time 0, 6, and 24 h. ACTH concentrations at the end of saline or CRH infusions were less than 45 pg/mL; neither saline nor CRH infusions evoked early changes in 17-OHP levels. Within 3 h of CRH infusion, DHEAS increased by 46%, on average; androstenedione increased 2.5-fold and DHEA increased 5-fold during CRH infusion (all P < 0.0001 compared with saline). There was no detectable CRH effect on the responses of LH, FSH, DHEA, DHEAS, 17-OHP, androstenedione, testosterone, and estradiol 24 h after GnRH agonist administration; five of 12 girls had elevated 17-OHP responses suggestive of OH. In conclusion, CRH was found to be a potent adrenal androgen secretagogue in adolescent girls with hyperandrogenism after PP. In this study, CRH failed to detectably affect the ovarian androgen response to gonadotropins.
ISSN: 0021-972X
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Section Newborn (-)
× corresponding author
# (joint) last author

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