Title: Insulin gene variable number of tandem repeat genotype and the low birth weight, precocious pubarche, and hyperinsulinism sequence
Authors: Ibanez, L ×
Ong, K
Potau, N
Marcos, MV
de Zegher, Francis
Dunger, D #
Issue Date: 2001
Series Title: Journal of Clinical Endocrinology and Metabolism vol:86 issue:12 pages:5788-5793
Conference: date:Univ Barcelona, Hosp Sant Joan De Deu, Endocrine Unit, Barcelona 08950, Spain; Univ Cambridge, Dept Pediat, Cambridge CB2 2QQ, England; Autonomous Univ Barcelona, Hosp Maternoinfantil Vall Hebron, Hormonal Lab, Barcelona, Spain; Consorci Hosp Terrassa, Endocrine Unit, Barcelona 08227, Spain; Katholieke Univ Leuven, Dept Pediat, B-3000 Louvain, Belgium
Abstract: Low birth weight associations with hyperinsulinemia and other adulthood disease risk factors have been described in several cohorts, including girls who present with precocious pubarche (pubic hair <8 yr). We hypothesized that these associations might be influenced by the insulin gene (INS) variable number of tandem repeat (VNTR), a common polymorphism related to INS transcription levels. In 141 Caucasian girls, who presented with precocious pubarche, hyperinsulinemia was assessed from mean insulin levels, during an oral glucose load (MR), and insulin sensitivity was determined from fasting glucose and insulin levels. Fasting blood lipid profiles were also measured. DNA was genotyped for INS VNTR allele class (I or III) in precocious pubarche girls and in 140 age- and body mass index-matched control girls. INS VNTR genotype distribution was similar in precocious pubarche and control girls. However among precocious pubarche girls. INS VNTR genotype was related to the severity of phenotype; III and I/III genotypes had lower birth weights (P < 0.01), higher MSI (P < 0.005), and lower insulin sensitivity (P < 0.005) than III/III girls. In precocious pubarche girls, birth weight was also inversely related to MSI (r = -0.29; P < 0.0005), total cholesterol (r = -0.38; P < 0.0005), and low density lipoprotein cholesterol (r = -0.44; P < 0.0005). Using logistic regression, additive adverse effects of I/* genotype and low birth weight were seen on MSI (P = 0.03 and P = 0.004, respectively) and total cholesterol levels (P = 0.01 and P < 0.0001). In summary, in girls who presented with precocious pubarche, hyperinsulinemia and dyslipidemia were related to both low birth weight and INS VNTR class I alleles. A similar interaction between genotype and intrauterine growth restraint may underlie other reported links between low birth weight and adulthood disease risks.
ISSN: 0021-972X
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Section Newborn (-)
× corresponding author
# (joint) last author

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