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Title: High-dose growth hormone treatment of short children born small for gestational age
Authors: de Zegher, Francis
Maes, M
Gargosky, SE
Heinrichs, C
DuCaju, MVL
Thiry, G
DeSchepper, J
Craen, M
Breysem, L
Lofstrom, A
Jonsson, P
Bourguignon, JP
Malvaux, P
Rosenfeld, RG #
Issue Date: 1996
Publisher: ENDOCRINE SOC
Series Title: Journal of Clinical Endocrinology and Metabolism vol:81 issue:5 pages:1887-1892
Conference: date:UNIV LOUVAIN,DEPT PEDIAT,LOUVAIN,BELGIUM; UNIV LOUVAIN,DEPT RADIOL,LOUVAIN,BELGIUM; PHARMACIA PEPTIDE HORMONES,STOCKHOLM,SWEDEN; OREGON HLTH SCI UNIV,DEPT PEDIAT,PORTLAND,OR 97201; BELGIAN STUDY GRP PEDIAT ENDOCRINOL,LOUVAIN,BELGIUM; FREE UNIV BRUSSELS,DEPT PEDIAT,B-1050 BRUSSELS,BELGIUM; UNIV ANTWERP,DEPT PEDIAT,B-2020 ANTWERP,BELGIUM; STATE UNIV GHENT,DEPT PEDIAT,B-9000 GHENT,BELGIUM; UNIV LIEGE,DEPT PEDIAT,LIEGE,BELGIUM
Abstract: The effect of GH administration was evaluated over 2 yr in 50 short, prepubertal, non-GH deficient children born small for gestational age, who had been randomly allocated to a group receiving no treatment or daily sc GH treatment at a dose of 0.2 or 0.3 IU/kg. At the start of the study, mean age was 5.2 yr, bone age was 4.0 yr, height sos was -3.5, height velocity sos was -0.8, weight SDS was -2.7, and body mass index SDS was -1.9. Catch-up growth was observed in none of the untreated and all of the treated children. The response to GH treatment included a near doubling of growth velocity and of weight gain and a mean height increment of more than 2 SDS. GH treatment was associated with a distinct acceleration of bone maturation. The differences between the growth responses evoked by the two GH doses were minor. The prepubertal GH-induced catch-up growth was associated with elevated serum concentrations of insulin, insulin-like growth factor-I, insulin-like growth factor binding protein-3, and osteocalcin, whereas insulin-like growth factor-II levels remained unaltered. GH treatment was well tolerated. In conclusion, high-dose GH administration over 2 yr is emerging as a potential therapy to increase the short stature that results from insufficient catch-up growth in young children born small for gestational age. The long-term impact of this approach remains to be delineated.
ISSN: 0021-972X
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Section Newborn (-)
# (joint) last author

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