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Title: Growth hormone treatment induces a dose-dependent catch-up growth in short children born small for gestational age: A summary of four clinical trials
Authors: Wilton, P ×
AlbertssonWikland, K
Butenandt, O
Chaussain, JL
de Zegher, Francis
Jonsson, B
Lofstrom, A #
Issue Date: 1997
Publisher: KARGER
Series Title: Hormone research vol:48 issue:Suppl. 1 pages:67-71
Conference: date:UNIV GOTHENBURG,DEPT PEDIAT,GOTHENBURG,SWEDEN; UNIV MUNICH,DEPT PEDIAT,MUNICH,GERMANY; HOP ST VINCENT DE PAUL,DEPT PEDIAT,F-75674 PARIS,FRANCE; CATHOLIC UNIV LEUVEN,DEPT PEDIAT,B-3000 LOUVAIN,BELGIUM
Abstract: In the present study, data from 230 short children born small for gestational age, who were participating in four clinical trials, were pooled and analysed. At the start of GH treatment, median age and height SDS were 5.3 years and -3.2 SDS, respectively. A dose-dependent increase in height SDS was observed following 2 years of GH treatment: 1.1, 1.7 and 2.5 SDS for the three GH treatment groups (0.1, 0.2 and 0.3 IU/kg/day, respectively), compared with an increase of 0.14 SDS in the control group. In a multiple regression analysis, four variables were found to correlate independently with the gain in height SDS following 2 years of GH treatment. These are given below in order of importance: gain in height SDS = 7.7 x dose of GH (IU/kg/day) -0.11 x age (years) -0.08 x parental-adjusted height SDS + 0.05 x birth length SDS (SD = 0.5; r(2) = 0.64). At the end of the 2-year study period, a total of 48%, 66% and 90% of patients in the groups given GH at 0.1, 0.2 and 0.3 IU/kg/day, respectively, had a parental-adjusted height greater than -1.0 SDS.
ISSN: 0301-0163
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Section Newborn (-)
× corresponding author
# (joint) last author

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