Title: Antenatal urodynamic studies in the fetal lamb: experimental protocol and preliminary results
Authors: de Tayrac, Renaud ×
Cuckow, Peter Malcom
Devlieger, Roland
Deprest, Jan
Bogaert, Guy
Ville, Yves #
Issue Date: Mar-2003
Series Title: Prenatal Diagnosis vol:23 issue:3 pages:187-92
Abstract: OBJECTIVES: To set up a fetal lamb model for intrauterine fetal urodynamic studies. METHODS: Fourteen fetal lambs underwent placement of a bladder catheter at a mean gestational age of 87 days. Three fetuses also had a partial urethral obstruction by the simultaneous placement of a peri-urethral constricting ring. Urodynamic and ultrasound studies were performed weekly by the filling cystometry method. RESULTS: Hundred and six voiding cycles were recorded during 25 urodynamic studies between 84- and 133-days gestation. All voiding profiles were biphasic with a mean duration of 4.2 min (range 1-10), a mean voiding pressure of 23 cm of water (range 7-33) and a mean periodicity of 19.2 min (range 11-50). The obstructed animals had bladder overactivity. This correlated with ultrasound and post-mortem findings of megacystis and bilateral hydroureteronephrosis. The fetal mortality rate was 85.7% and the mean duration of survival post surgery was 45 +/- 5.7 days. CONCLUSION: Serial urodynamic studies could be performed in a fetal lamb model. Following partial urethral obstruction, bladder overactivity was observed.
ISSN: 0197-3851
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Urology Section (-)
Basic Research in Gynaecology Section (-)
Foetal Medicine Section (-)
× corresponding author
# (joint) last author

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