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Title: Report of an international survey of molecular genetic testing laboratories
Authors: McGovern, Margaret M ×
Elles, Rob
Beretta, Isabella
Somerville, Martin J
Hoefler, Gerald
Keinanen, Mauri
Barton, David
Carson, Nancy
Dequeker, Elisabeth
Brdicka, Radim
Blazkova, Alena
Ayme, Segolene
Schnieders, Birgit
Mueller, Clemens R
Dalen, Vibeke
Martinez, Armando Albert
Kristoffersson, Ulf
Ozguc, Meral
Mueller, Hansjakob
Boone, Joe
Lubin, Ira M
Sequeiros, Jorge
Taruscios, Domenica
Williamson, Bob
Mainland, Lynn
Yoshikura, Hiroshi
Ronchi, Elettra #
Issue Date: 2007
Publisher: Karger
Series Title: Community Genetics vol:10 issue:3 pages:123-131
Abstract: Objective: To collect data on the practices of molecular genetic testing (MGT) laboratories for the development of national and international policies for quality assurance (QA). Methods: A web-based survey of MGT laboratory directors (n = 827; response rate 63%) in 18 countries on 3 continents. QA and reporting indices were developed and calculated for each responding laboratory. Results: Laboratory setting varied among and within countries, as did qualifications of the directors. Respondents in every country indicated that their laboratory receives specimens from outside their national borders (64%, n = 529). Pair-wise comparisons of the QA index revealed a significant association with the director having formal training in molecular genetics (p < 0.005), affiliation with a genetics unit (p = 0.003), accreditation of the laboratory (p < 0.005) and participation in proficiency testing (p < 0.005). Research labs had a lower mean report score compared to all other settings (p < 0.05) as did laboratories accessioning <150 samples per year. Conclusion: MGT is provided under widely varying conditions and regulatory frameworks. The data provided here may be a useful guide for policy action at both governmental and professional levels.
ISSN: 1422-2795
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Human Mutations and Polymorphisms Section (-)
Biomedical Quality Assurance Research Unit
× corresponding author
# (joint) last author

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