Title: Heuristic feed rate profiles for optimal yield and productivity of fed-batch bioprocesses
Authors: Claes, Johan
Geeraerd, Annemie
Van Impe, Jan # ×
Issue Date: 1999
Series Title: Chemical engineering communications vol:172 pages:189-216
Abstract: The optimization of two important classes of fed-batch fermentation processes with respect to the limiting substrate feed rate is considered:(i) growth of one biomass on one limiting substrate, and (ii) growth and product formation on one substrate. For these two types of bioprocesses, two different performance criteria are compared: yield and productivity. Heuristic feed rate profiles are derived based on (i) the optimal control solution according to the minimum principle, and (ii) the qualitative behavior of the specific rates for growth and possibly product formation. For biomass production processes, it is illustrated that the heuristic strategy coincides exactly with the optimal control solution, while its structure is independent of the performance index considered. For product formation processes, it is illustrated that the same heuristic approach can be used to optimize both yield and productivity in spite of the well known conflict between them.
ISSN: 0098-6445
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Division of Mechatronics, Biostatistics and Sensors (MeBioS)
Bio- & Chemical Systems Technology, Reactor Engineering and Safety Section
Bioengineering Technology TC, Technology Campus Geel
Technologiecluster Bioengineering Technologie
× corresponding author
# (joint) last author

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