Title: The role of the solvent in the asymmetric hydrogenation of beta-keto esters with Ru-BINAP
Authors: Wolfson, A ×
Vankelecom, Ivo
Geresh, S
Jacobs, Pierre #
Issue Date: 2003
Series Title: Journal of molecular catalysis. A: Chemical vol:198 issue:1-2 pages:39-45
Conference: date:Katholieke Univ Leuven, Fac Agr & Agr Biol Sci, Ctr Surface Chem & Catalysis, B-3001 Louvain, Belgium; Ben Gurion Univ Negev, Dept Biotechnol Engn, Inst Appl Biosci, IL-84105 Beer Sheva, Israel
Abstract: The influence of the solvent on the asymmetric hydrogenation of methyl acetoacetate, as a representative beta-keto esters, with Ru-BINAP was studied. The highest activities were measured when the reaction proceeded in methanol, ethanol or isopropanol. These solvents, which also act as proton donors, accelerate product release from the reaction intermediate. The presence of water in the reaction mixture has been found to be detrimental for both activity and enantioselectivity. All results could be explained by the existence of two different solvent dependent reaction pathways for product release. (C) 2002 Elsevier Science B.V. All fights reserved.
ISSN: 1381-1169
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Centre for Surface Chemistry and Catalysis
× corresponding author
# (joint) last author

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