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Title: Enhancement of the enantioselectivity in the epoxidation of sterically hindered substrates by decreasing the contribution of the blank reaction
Authors: Janssen, KBM ×
Parton, RF
Jacobs, Pierre #
Issue Date: 1997
Publisher: PERGAMON-ELSEVIER SCIENCE LTD
Series Title: Tetrahedron: asymmetry vol:8 issue:18 pages:3039-3042
Abstract: In the case of asymmetric epoxidation reactions catalysed by Jacobsen's catalyst, the substrate/catalyst ratios used are low. Often additives, such as N-oxides, are employed to enhance the enantioselectivity of the reaction. We have found that for reactions of sterically hindered, less reactive substrates, a non-selective blank reaction competes with the catalysed reaction. When low substrate/catalyst ratios or additives are used, an acceleration of the epoxidation reaction is observed. As a result a larger difference in rate with the blank reaction occurs, resulting in an increase in the enantioselectivity. (C) 1997 Elsevier Science Ltd.
ISSN: 0957-4166
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Centre for Surface Chemistry and Catalysis
× corresponding author
# (joint) last author

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