Title: Factors influencing local relapse and survival and results of salvage treatment after breast-conserving therapy in operable breast cancer: EORTC trial 10801, breast conservation compared with mastectomy in TNM stage I and II breast cancer
Authors: van Dongen, J A ×
Bartelink, H
Fentiman, I S
Lerut, Antoon
Mignolet, F
Olthuis, G
van der Schueren, E
Sylvester, R
Tong, D
Winter, J
Issue Date: 1992
Series Title: European journal of cancer vol:28A issue:4-5 pages:801-805
Abstract: A (modified) radical mastectomy (RM) was compared with breast-conserving therapy (BCT) in stage I and stage II breast cancer patients. Treatment of the study arm comprised lumpectomy, axillary clearance and radiotherapy to the breast (50 Gy in 5 weeks external irradiation and a boost with iridium implant of 25 Gy). 902 patients were included. There were 734 TNM stage II patients. Patients with microscopically incomplete excision of the tumour were not excluded. After a median follow-up of 6 years, overall survival and local recurrence rates do not differ significantly between the two study arms. Actuarial survival at 8 years was 73% after RM and 71% after BCT; actuarial local recurrence at 8 years was 9% and 15%, respectively. In the mastectomy group tumour size did not affect local relapse, but after BCT the incidence of local recurrences was higher for tumours of 2-5 cm (16%) than for smaller tumours (7%) (at 8 years, P = 0.08). Results of salvage treatment for local recurrence so far were similar in both the BCT and the mastectomy group.
ISSN: 0959-8049
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Thoracic Surgery
× corresponding author
# (joint) last author

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