Title: The alcoholysis reaction of isocyanates giving urethanes: Evidence for a multimolecular mechanism
Authors: Raspoet, G ×
Nguyen, Minh Tho
McGarraghy, M
Hegarty, AF #
Issue Date: 1998
Series Title: Journal of Organic Chemistry vol:63 issue:20 pages:6878-6885
Conference: date:Univ Louvain, Dept Chem, B-3001 Heverlee, Belgium; Natl Univ Ireland Univ Coll Dublin, Dept Chem, Dublin 4, Ireland
Abstract: A kinetic and mechanistic investigation of the catalyzed alcoholysis of isocyanates was undertaken. Both experimental and theoretical results showed that the alcoholysis should be understood by a multimolecular intervention of the alcohols. The alcoholysis of isocyanate was examined experimentally for 2-propanol and cyclohexanol in low and high concentrations. It is suggested that either two or three molecules of the alcohol are implicated from the kinetic study, while the reaction with trimers becomes dominant at high alcohol concentrations. In accordance with these results, theoretical study suggests an active participation of at least three alcohol molecules in a reacting supersystem, giving rise to a genuine effect. The detailed reaction mechanism for the alcoholysis reaction by methanol and methanol clusters (HN=C=O + n(CH3OH), n = 1-3) was modeled by ab initio methods, both in the gas phase and in solution. The nucleophilic addition occurs in a concerted way across the N=C bond of the isocyanate rather than across the C=O, similar to the isocyanate hydrolysis. The bulk solvent effect, which is treated by a polarizable continuum model (PCM), does not affect the preference of the alcohol to attack across the N=C bond as pointed out by the gas-phase values.
ISSN: 0022-3263
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Quantum Chemistry and Physical Chemistry Section
× corresponding author
# (joint) last author

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