Title: Theoretical study of hydrogenation of thiouracils and their base pairs with adenine
Authors: Eriksson, LA ×
Kryachko, ES
Nguyen, Minh Tho #
Issue Date: 2004
Series Title: International journal of quantum chemistry vol:99 issue:5, Sp. Iss. SI pages:841-853
Conference: date:Univ Uppsala, Dept Biochem, Box 576, S-75123 Uppsala, Sweden; Katholieke Univ Leuven, Dept Chem, B-3001 Heverlee, Belgium
Abstract: The purpose of the present work is to employ theoretical chemical tools to explore the subtle features of the hydrogenation of uracil and its related thioderivatives. The reactions of hydrogenation are followed for the free uracil, 2-thiouracil, 4-thiouracil, and 2,4-dithiouracil as well as for adenine-thiouracil base pairs. It is shown for the first time that, in contrast to the hydrogenation pathways to the carbon atoms C-5 and C-6 of the studied molecules, characterized by the transition states, the hydrogenations at the sulphur atoms for thiouracils are barrierless and thus the latter are the kinetically most favorable pathways for hydrogenation. As also shown, these features are retained under the hydrogenation of the adenine-thiouracil base pairs. The present study clearly demonstrates that the base pairing destruction is the key radiation-induced lesion in the adenine-4-thiouracil and adenine-2,4-dithiouracil base pairs when the hydrogen radical H-., as one of the primary radiation products, resides at the sulphur atom S-4. (C) 2004 Wiley Periodicals, Inc.
ISSN: 0020-7608
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Quantum Chemistry and Physical Chemistry Section
× corresponding author
# (joint) last author

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