Title: Acute phase protein concentrations in serum and milk from healthy cows, cows with clinical mastitis and cows with extramammary inflammatory conditions
Authors: Nielsen, BH ×
Jacobsen, S
Andersen, PH
Niewold, Theodoor
Heegaard, PMH #
Issue Date: 2004
Series Title: The veterinary record vol:154 issue:12 pages:361-365
Conference: date:Royal Vet & Agr Univ, Dept Clin Studies, DK-1870 Frederiksberg C, Denmark; ID Lelystad BV, Inst Anim Sci & Hlth, Res Grp Anim Physiol & Hlth, NL-8200 AB Lelystad, Netherlands; Danish Vet Inst, Dept Immunol & Biochem, DK-1790 Copenhagen V, Denmark
Abstract: The concentrations of the two acute phase proteins, serum amyloid A and haptoglobin, in serum and milk were compared in 10 cows with clinical mastitis, 11 cows with extramammary inflammatory conditions and 10 clinically healthy control cows. The concentrations of both acute phase proteins were higher in the serum and milk of the cows with mastitis than in the cows in the other two groups. Four of the cows with extramammary inflammatory conditions had serum amyloid A concentrations in serum above 100 mug/ml, but negligible concentrations in milk, indicating that a pathogen must be present in the mammary gland for serum amyloid A to accumulate in milk. The acute phase protein concentrations in milk increased significantly with increasing somatic cell count, suggesting that they may be indicators of the severity of an infection.
ISSN: 0042-4900
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Division of Livestock-Nutrition-Quality (-)
× corresponding author
# (joint) last author

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