Title: Plasma intestinal fatty acid binding protein (I-FABP) concentrations increase-following intestinal ischemia in pigs
Authors: Niewold, Theodoor ×
Meinen, M
van der Meulen, J #
Issue Date: 2004
Series Title: Research in veterinary science vol:77 issue:1 pages:89-91
Conference: date:Res Grp Anim Physiol & Hlth, Div Anim Resources Dev, Anim Sci Grp, NL-8200 AB Lelystad, Netherlands
Abstract: Intestinal fatty acid binding protein (I-FABP) is an intracellular epithelial protein in the intestinal mucosa of many animals. IFABP appears in the circulation following epithelial damage, and in humans, is proven to be a parameter for damage to the mucosa. In this paper, an ELISA test designed for human I-FABP analysis was used to assay pig blood samples. The test recognized I-FABP cloned from pig small intestine and expressed in Escherichia coli. Furthermore, in our experimental model of (low flow) intestinal ischemia and reperfusion a significant rise in plasma I-FABP concentrations 15-30 min after clamping of the mesenteric artery was demonstrated. This is the first report that in pigs circulating I-FABP is a useful marker for (mild) intestinal injury, and could possibly be used to monitor (intestinal) health in clinical practice. (C) 2004 Elsevier Ltd. All rights reserved.
ISSN: 0034-5288
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Division of Livestock-Nutrition-Quality (-)
× corresponding author
# (joint) last author

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