ITEM METADATA RECORD
Title: CHARACTERIZATION OF PROTEOGLYCANS AND GLYCOSAMINOGLYCANS IN BOVINE RENAL AA-TYPE AMYLOIDOSIS
Authors: Niewold, Theodoor ×
LANDEIRA, JMF
VANDENHEUVEL, LPWJ
ULTEE, A
TOOTEN, PCJ
VEERKAMP, JH #
Issue Date: 1991
Publisher: SPRINGER VERLAG
Series Title: Virchows Archiv. B, Cell pathology including molecular pathology vol:60 issue:5 pages:321-328
Conference: date:UNIV COMPLUTENSE MADRID,FAC VET,DEPT HISTOL & PATHOL ANAT,MADRID 3,SPAIN; CATHOLIC UNIV NIJMEGEN,DEPT BIOCHEM,NIJMEGEN,NETHERLANDS
Abstract: Highly sulfated glycosaminoglycans (GAG) or proteoglycans (PG), especially heparan sulfate (HS) and heparan sulfate proteoglycan (HSPG), are considered to be intimately associated with amyloid deposits in different types of amyloidosis. Based on this relationship an important role for HS has been suggested in amyloidogenesis. The present immunohistological and ultrastructural study shows that in bovine renal AA-amyloidosis, sulfated GAG/PG was not restricted to amyloid deposits proper and that areas without GAP/PG were also present within the amyloid. Both glomerular and papillary amyloid contained HS (PG), and the latter also contained chondroitin sulfate (CS) and dermatan sulfate (DS), suggesting a correlation between the location of the amyloid and the type of GAG/PG deposited. Amyloid P component (AP) had a distribution similar to that of HSPG, confirming their affinity-based relationship. The GAG types found ultrastructurally in amyloid fibril preparations of glomerular and papillary amyloid isolated from the same kidney, reflected the immunohistological findings. HS was shown to be the predominant GAG in all papillary amyloid fibril extracts. Taking into account the chemico-physical properties of HS, it cannot be excluded that this predominance is introduced by the purification procedure. These results suggest that the association of GAG/PG and amyloid is not necessarily mutually obligatory and that the proposed importance of GAG in amyloidogenesis is disputable.
ISSN: 0340-6075
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Division of Livestock-Nutrition-Quality (-)
× corresponding author
# (joint) last author

Files in This Item:

There are no files associated with this item.

Request a copy

 




All items in Lirias are protected by copyright, with all rights reserved.

© Web of science