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Title: Orlistat treatment is safe in overweight and obese liver transplant recipients: a prospective, open label trial
Authors: Cassiman, David ×
Roelants, M
Vandenplas, Gerda
Van der Merwe, Schalk
Mertens, Ann
Libbrecht, Louis
Verslype, Chris
Fevery, Johan
Aerts, Raymond
Pirenne, Jacques
Muls, Erik
Nevens, Frederik #
Issue Date: Dec-2006
Publisher: Springer International
Series Title: Transplant International vol:19 issue:12 pages:1000-5
Abstract: Obesity is a frequent complication following liver transplantation and is insufficiently responsive to dietary and life style advice. We studied the safety of orlistat treatment in obese and overweight liver transplant recipients (n = 15) on a stable tacrolimus-based immunosuppressive regimen. For safety reasons, the treatment period was restricted (6 months 120 mg t.i.d., 3 months 120 mg daily). Three patients dropped out, tacrolimus dose was adjusted in six of 12 remaining patients (dose reduction in 4, increase in 2, P = N.S.). All dose adjustments occurred during the 6 months of orlistat 120 mg t.i.d. therapy. No drug intolerance, adverse events or episodes of rejection occurred during the study. Efficacy of orlistat treatment in this population could not be shown, because a formal control population was not included in this safety trial. Moreover, only a significant decrease of waist circumference (P < 0.01 versus start of the study), but not of weight or body mass index, was achieved in the treated group. Orlistat treatment is well tolerated in liver transplant recipients and can be started safely, provided immunosuppressive drug levels and dietary adherence are closely monitored.
URI: 
ISSN: 0934-0874
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Hepatology
Translational Cell & Tissue Research
Abdominal Surgical Oncology
Laboratory of Abdominal Transplantation
Environment and Health - miscellaneous
Department of Experimental Medicine (-)
Clinical and Experimental Endocrinology
Laboratory of Nephrology
× corresponding author
# (joint) last author

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