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Title: Different gastritis features are linked to different gastric neoplasms
Authors: Driessen, A
Ectors, Nadine
Van Cutsem, Eric
Penninckx, Freddy
Filez, Ludo
Pittaluga, S
Delabie, J
Peeters, C
Geboes, Karel #
Issue Date: Oct-1999
Series Title: Gastroentérologie clinique et biologique vol:23 issue:6-7 pages:747-53
Abstract: OBJECTIVES: Helicobacter pylori infection induces gastritis, which may evolve to carcinoma or lymphoma. Whether duration of infection and inflammation pattern determine the outcome of the neoplastic process is not known. The aim of this study was to investigate the features of the gastritis associated with neoplasia. METHODS: Gastritis found in association with carcinoma (100 cases) and lymphoma (45 cases) were graded using the Sydney system. RESULTS: In particular in the antrum, gastric carcinomas, in particular of the intestinal type, were associated with a chronic (94%, n = 34/36) atrophic (92%, n = 33/36) gastritis and intestinal metaplasia (81%, n = 29/36). In diffuse type carcinomas inflammation was either absent or mild. An active (64%, n = 16/25), chronic gastritis (100%, n = 25/25) with lymphoid hyperplasia (72%, n = 18/25) was found in marginal zone cell lymphoma. CONCLUSIONS: Our study shows that the (pre)atrophic phases of inflammation are associated with gastric carcinomas. In contrast the active phase of inflammation, characterized by severe activity as well as severe chronicity, is found next to marginal zone cell lymphoma.
ISSN: 0399-8320
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Translational Cell & Tissue Research
Abdominal Surgical Oncology
Translational Research in GastroIntestinal Disorders
Clinical Digestive Oncology (+)
# (joint) last author

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