Title: Anti-HIV activity of a series of cosalane amino acid conjugates
Authors: Santhosh, Kalpathy C ×
De Clercq, Erik
Pannecouque, Christophe
Witvrouw, Myriam
Loftus, Tracy L
Turpin, Jim A
Buckheit, Robert W
Cushman, Mark #
Issue Date: Nov-2000
Series Title: Bioorganic and medicinal chemistry letters vol:10 issue:22 pages:2505-2508
Abstract: The binding of the anti-HIV agent cosalane to CD4 is thought to involve ionic interactions of negatively charged carboxylates of the ligand with positively charged residues on the surface of the protein. The purpose of the present study was to examine the hypothesis that the two carboxyl groups of cosalane could be sacrificed through conjugation to amino acids, and the anti-HIV activity still be retained, provided that at least two new carboxyl groups are contributed by the amino acid residues.
Description: Afdeling Virologie en chemotherapie. Afdeling Klinische en epidemiologische virologie.

ISSN: 0960-894X
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Virology and Chemotherapy (Rega Institute)
Molecular Virology and Gene Therapy
Rega Institute for Medical Research (-)
× corresponding author
# (joint) last author

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