This item still needs to be validated !
Title: Recurrent chromosome aberrations in fibrous dysplasia of the bone: a report of the CHAMP study group
Authors: Dal Cin, Paola ×
Sciot, Raphael
Brys, Peter
De Wever, Ivo
Dorfman, Howard
Fletcher, Christopher D. M
Jonsson, Kjell
Mandahl, Nils
Mertens, Fredrik
Mitelman, Felix
Rosai, Juan
Rydholm, Anders
Samson, Ignace
Tallini, Giovanni
Vanni, Roberta
Willén, Helena
Van den Berghe, Herman #
Issue Date: Oct-2000
Publisher: Elsevier Science Pub. Co.
Series Title: Cancer genetics and cytogenetics vol:122 issue:1 pages:30-32
Abstract: The nosologic status of fibrous dysplasia (FD), a well-known and relatively common bone lesion, is controversial. Information collected by the CHromosomes And MorPhology (CHAMP) study group on published and unpublished cases of fibrous dysplasia shows the presence of clonal chromosome changes in at least a proportion of these lesions. The chromosome aberrations found in FD lesions have been quite variable and have included both structural and numerical changes. Two of the three cases investigated at the study group had trisomy 2 as the sole acquired anomaly. Combined with previously published data, +2 and rearrangements involving chromosome band 12p13 have each been detected in 3 of 8 cases with abnormal karyotype of 11 in which chromosomal analysis has been performed, suggesting that FD is a neoplastic lesion rather than a "dysplastic" process, as has been generally believed and as implied by its very name.
Description: Afdeling Radiologie. Departement Menselijke erfelijkheid. Afdeling Morfologie en moleculaire pathologie. Afdeling Oncologische heelkunde.
ISSN: 0165-4608
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Translational Cell & Tissue Research
Department of Human Genetics - miscellaneous
Clinical Genetics Section (-)
Surgical Oncology
× corresponding author
# (joint) last author

Files in This Item:

There are no files associated with this item.

Request a copy


All items in Lirias are protected by copyright, with all rights reserved.

© Web of science