Title: Cytogenetic, clinical, and morphologic correlations in 78 cases of fibromatosis: a report from the CHAMP Study Group
Authors: De Wever, Ivo ×
Dal Cin, Paola
Fletcher, Christopher D. M
Mandahl, Nils
Mertens, Fredrik
Mitelman, Felix
Rosai, Juan
Rydholm, Anders
Sciot, Raphael
Tallini, Giovanni
Van den Berghe, Herman
Vanni, Roberta
Willén, Helena #
Issue Date: Oct-2000
Publisher: Williams & Wilkins
Series Title: Modern Pathology vol:13 issue:10 pages:1080-5
Abstract: Whether fibromatoses are neoplastic or reactive lesions has long been controversial and the relationship, if any, between the superficial and deep forms (desmoid tumors) are poorly understood. Clinical, pathologic, and cytogenetic data of 78 cases of fibromatosis were analyzed and correlated with each other. The results demonstrate that clonal chromosome aberrations are a common feature of this entity, being present in 46% of desmoid tumors, although less frequent in the superficial types (10%). In the deep-seated extra-abdominal fibromatoses, trisomies 8 and 20 and loss of 5q material were the only recurrent features. No correlation between +8 and local recurrence was found. Our findings provide additional evidence for the neoplastic nature of fibromatoses.
Description: Afdeling Oncologische heelkunde. Departement Menselijke erfelijkheid.
ISSN: 0893-3952
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Department of Human Genetics - miscellaneous
Translational Cell & Tissue Research
Clinical Genetics Section (-)
Surgical Oncology
× corresponding author
# (joint) last author

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